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Medical Applications of Remote Sensing

The next three pages are concerned with the applications of remote sensing to the medical profession's need to examine humans and animals by sophisticated imaging instruments. Many of the techniques of using high-powered instruments to send electromagnetic and sonic waves into the human target (we shall assume that "animal" is understood implicitly to be included since at least some of these instruments have been used to examine dogs, cats, horses, etc.) fall within the broader definition of remote sensing - electromagnetic radiation photons (at different wavelengths) or sonic wave trains are generated and coupled to the body and then detected as transmitted, absorbed, or reflected signals to an external detector a short distance away. Most medical remote sensing is of the active mode, i.e., EM radiation or acoustical waves generated by the instrument are sent into or through the body. Some examinations of bodily functions depend on implanting (by injection or swallowing) a source of radiation, such as radioactive element(s) as tracers which can be sensed by appropriate detectors as they move about (as in the blood) or concentrate within organs - this approach is analogous to passive remote sensing.

Two common uses of imaging probes are an endoscopy and a colonoscopy. This again had elements of classical remote sensing (electromagnetic radiation associated with the scanning light) except that the signal from the moving target beyond direct reach passed through a flexible fiber optic cord rather than air or empty space. As introductory examples, below are two of the results of probing to into the human digestive system and bladder:

Endoscopic imaging of the Duodenum. <p><div align=Areas within a bladder; the circularity is due to the cystoscope's field of view.

The subject of medical remote sensing (more commonly referred to as medical imaging) is now a major topic covered on the Internet. A good synopsis is online at this Wikepedia entry. Of general interest is this Imaginis site.

Before we begin, a word about the human body (for more details, consult the City University of New York website. The anatomy of the body is treated in several general categories, chief of which are the human skeleton, the internal organs, and the heart. These four illustrations are almost self-explanatory:

In the Tutorial, we will cover these methods: X-ray Radiography; X-ray Fluoroscopy; Computer Assisted Tomography (CAT scans); Magnetic Resonance Imaging (MRI); SPECT (Single Photo Emission-Computed Tomography; Positron Emission Tomography (PET); CATscan-SPECT combined; Infrared Imaging Thermography; Ultrasound; and Endoscopy. PET and SPECT also fall in the realm of nuclear medicine. These various methods can produce "static" images or can be viewed in real time to examine "movements" within the body. Also, some methods concentrate on skeletal parts (bone), others on soft-tissue internal organs (e.g., brain; heart; kidneys); others on circulation and other functions. Most methods are used to detect abnormalities such as malignant growths, bone breaks, and disease effects.

Modern medical imaging began with an almost accidental discovery in the lab of Professor Wilhelm Roentgen in Germany on a November day in 1895.

Wilhelm Roentgen's Laboratory.

Roentgen was experimenting with a Crooke's Tube he had recently obtained from its inventor. This is a glass vessel from which air is withdrawn creating a near vacuum; at one end is an anode (positively charged) and at the other a cathode (negatively charged source of electrons); the tube is wired to be part of an electrical circuit. When a current is passed between these electrodes, the few particles within the tube are excited and fluoresce or glow (commonly blue or green); this results from the flow of high speed electrons (cathode rays) across the (voltage) potential difference imposed in the circuit. Roentgen had placed the Tube in a black box but to his amazement noted that a fluorescent screen nearby was glowing which he deduced to be excitement of its phosphors by radiation escaping the box. This unknown (X) radiation he simply labelled X-rays (they are also called Roentgen rays). As he studied their properties, he experimented by putting a hand on a fluorescent screen directly in the path of this radiation, getting this famous picture:

Colorized version of the first image of an X-rayed hand.

Soon others were experimenting with X-rays. The first medical uses of X-ray machines occurred within a year. Roentgen's achievement was recognized in 1901 when he received the first Nobel Prize in Physics. A fascinating account of his discovery is given at this Internet site.

(The physics principles appropriate to this paragraph are reviewed on page I-2a.) X-rays are produced when electrons are impelled against an anode metal target (tungsten; copper; iron; molybdenum; platinum; others) as they pass through a vacuum tube at high speeds driven by voltages from 10 to 1000 kilovolts (kV). When incoming electrons interact with inner electrons in the metal, these latter are driven momentarily to higher energy levels (these orbital electrons are pushed into outer orbitals); when these excited electrons drop back to their initial orbits (a transition from a higher to a lower energy level), the energy they acquired is given off as radiation, including X-rays (wavelengths from 0.03 to 3.0 nanometers). Some of the scattered X-rays are collimated into beams (typically at conical angles up to 35°) that are directed towards targets (such as the human body). Soft body tissue absorbs less X-rays, i.e., passes more of the radiation, whereas bone and other solids prevent most of the X-rays from transmitting through their mass. (X-rays have other uses, such as examining metals for flaws or determining crystal structure.) Here is a diagram of a typical X-ray machine setup:

Schematic diagram of an x-ray generating tube assembly and of its using in examining the human body.

Two classes of detectors record the X-ray-generated image: 1)Photographic film, in which the difference in gray levels or tones relates to varying absorption of the radiation in the beam impinging on the target. The convention is to use the exposed film (X-rays act on the silver halide {see page I-12 of this Introduction} to reduce it to metal silver grains) as a negative. In its negative form, bone will appear nearly white (as said above, because bone absorbs efficiently, few X-rays strike the corresponding part of the film, leaving it largely unexposed; the soft tissue equivalents pass much more radiation and darken the film); 2) fluorescent screens, that include phospors (compounds that fluoresce or phosphoresce) coating a substrate; this occurs when electrons in the phosphors jump to higher level orbitals, with visible light given off either instantly when the electrons transition back to the lower state or with a time delay fractions of a second or seconds (afterglow), in a process similar to X-ray production; typical phosphors include Calcium tungstate or Barium lead sulphate; these screens in certain configurations allow realtime movements of the medical patient to be observed and the sreen images can be photographed or digitized.

X-ray radiology is still the most commonly used medical instrument technique. Here are a sequence of images that illustrate typical uses and results. The first is a chest X-ray:

Chest X-ray of a patient with healthy lungs; the skeletal bones are whitish since they absorb the radiation and thus the negative is not darkened, while the lungs appear dark because more of the radiation has passed through them to expose the film.

This next is a front and side view of the upper torso; the arrow points to a tuberculosis patch in the left lung:

Two chest X-rays of a patient with tuberculosis.

Here is a negative X-ray film image of the pelvic area:

X-ray of the pelvic-lower backbone-abdominal area of a patient.

This next X-ray image shows the upper arm and shoulder area. There is a slanted break across the arm (humerus bone) near the shoulder socket. Fractured in several places, this X-ray image is that

Upper arm with a small part of the fractured bone projecting to the left and down.

This next picture is a mammogram showing a growth in the female breast:

X-ray mammogram of a woman's breast showing veining and an abnormal growth.

The human skull is x-rayed mainly to spot signs of fracture. But, sometimes indications of tumors are present, as shown by the darker gray patch in the cranium of this individual's skull:

The upper part of the skull, with a dark patch due to a tumor.

The jaw and teeth are evident in this lateral view of the lower human skull:

The jaw and teeth structure in a human skull.

Most of us gain our first experience and insight into X-rays diagnostics when we have a small film inserted into our mouth and then the X-ray machine is placed against that part of our jaw. Here is a typical X-ray image of teeth, in which the whitest part of the negative corresponds to metal fillings (great absorbers):

Dental x-ray image of several teeth.

An important variation in X-ray radiography is Fluoroscopy. In this method, either chemicals that react with X-rays are swallowed or inserted as an enema or chemicals/dyes are injected into the blood stream. These tend to increase the contrast between soft tissue response in the parts of the body receiving these fluids and surrounding bone and tissue. This pictorially highlights abnormalities.

Barium sulphate is a good example. When swallowed (either at once or commonly in gulps), the "Barium Cocktail" is especially useful in examining the digestive track. In this image, an obstruction in the esophagus carrying food and liquids into the stomach is made evident:

X-ray fluoroscopic image of part of the esophagus and trachial areas in the neck and upper chest; normal conditions. X-ray fluoroscopic image of constricted esophagus.

The large intestine or colon is strikingly emphasized in a patient who has just received a Barium enema:

X-ray fluoroscopic image of the large intestine.

Still another variant is the Angiogram. This involves insertion of a catheter into an artery, accompanied by a dye that reacts to X-rays. It is commonly used to explore the areas in and around the heart. Here is a pair of views of the left ventricle of the heart when it is pumping and squeezing blood and thus contracting (systolic phase) and then expanding as blood is returned (diastolic phase):

Systolic phase of heart's beating; angiogram centered on the left ventricle. The corresponding diastolic phase.

This next image is an angiogram that has been colored to show blood vessels including the great trunk artery or aorta around the heart:

Angiogram of the heart.

Using special methods, angiogram-like images can be made for the blood vessels in the human head:

Angiogram of the head showing certain arteries and veins.

We move on now to a powerful new approach to medical imaging, based on the technique of tomography, which uses computers to assist in obtaining three-dimensional images or image slices when either X-rays or radioactive elements (nuclear medicine) are involved in producing radiation-based imagery.

Source: http://rst.gsfc.nasa.gov